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Methotrexate (Methotrexate)

Active Ingredient: (Methotrexate)
Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.
Batch Expiry Date: June 2017
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Methotrexate 2.5 mg

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Drug Uses

Methotrexate interferes with the growth of certain cells of the body, especially cells that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells.

Methotrexate is used to treat certain types of cancer of the breast, skin, head and neck, or lung. Methotrexate is also used to treat severe psoriasis and rheumatoid arthritis.

How to use

Use Methotrexate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Take Methotrexate by mouth with or without food. However, you should take it the same way each time in relation to food.
Drinking extra fluids while you are taking Methotrexate is recommended. Check with your doctor for instructions.
Be sure you understand exactly how much of Methotrexate to take and how often you should take it. Ask your doctor or pharmacist if you have any questions.
It may take several weeks for your symptoms to improve. Do not stop taking Methotrexate without checking with your doctor.
Methotrexate works best if each dose is taken at the scheduled time.
Continue to take Methotrexate even if you feel well. Do not miss any doses.
Drug Class and Mechanism

Methotrexate is an antimetabolite. It works to treat cancer and psoriasis by blocking an enzyme needed for cell growth. This helps to slow the growth of cancer cells and abnormal skin cells. Exactly how Methotrexate works to treat rheumatoid arthritis is unknown. It reduces symptoms of inflammation (e.g., pain, swelling, stiffness) caused by rheumatoid arthritis.

Missed Dose

If you miss a dose of Methotrexate, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.


Sore Methotrexate at 77 degrees F (25 degrees C). Brief storage between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Methotrexate out of the reach of children and away from pets.

Do not use Methotrexate if:

you are allergic to any ingredient in Methotrexate;
you are treating psoriasis or rheumatoid arthritis and you are pregnant or breast-feeding;
you are treating psoriasis or rheumatoid arthritis and abuse alcohol or have liver problems, an immunodeficiency syndrome (e.g., AIDS), bone marrow problems, or blood problems (e.g., anemia, low white blood cell count, low platelet count);
you have moderate or severe kidney problems;
you are taking acitretin.
Contact your doctor or health care provider right away if any of these apply to you.

Methotrexate may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Methotrexate with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
Check with your doctor before you drink alcohol while you are taking Methotrexate.
Nausea, vomiting, and loss of appetite are common with Methotrexate. Ask your doctor or pharmacist for ways to decrease these effects if they occur.
If vomiting or diarrhea occurs, you will need to take care not to become dehydrated. Contact your doctor for instructions.
Methotrexate may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Methotrexate. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
Methotrexate may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
Methotrexate may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
Do not receive a live vaccine (eg, measles, mumps) while you are taking Methotrexate. Talk with your doctor before you receive any vaccine.
Men who take Methotrexate should always use a condom when having sex with a woman who may become pregnant. Do this for as long as you take Methotrexate and for 3 months after you stop taking it.
Do not take more than the recommended dose or use for longer than prescribed without checking with your doctor.
Lab tests, including albumin levels, complete blood counts, and liver, lung, and kidney function, may be performed while you use Methotrexate. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Use Methotrexate with caution in the elderly; they may be more sensitive to its effects.
Methotrexate should be used with extreme caution in children younger than 2 years old; safety and effectiveness in these children have not been confirmed.
Pregnancy and breast-feeding: Methotrexate may cause birth defects and fetal and newborn death if you take it while you are pregnant. Do not become pregnant while you are using it. Use an effective form of birth control while you take Methotrexate and for at least 1 ovulatory cycle after you stop taking it. If you think you may be pregnant, contact your doctor right away. Methotrexate is found in breast milk. Do not breast-feed while taking Methotrexate.
Greater Manchester Interface Prescribing Group Shared Care Template ... Oral methotrexate is licensed to treat adults with rheumatoid arthritis and is also ... –Dermatological Sciences, The University of Manchester, Manchester Academic ... monitoring of methotrexate with respect to hepatotoxicity when used in the ... University of Manchester ... The Rheumatoid Arthritis Methotrexate Starters ( RAMS) study is a new study looking at the response to methotrexate in patients with ... Aug 20, 2011 Methotrexate is the most effective systemic agent in psoriasis and has .... the MANCHESTER guidelines for monitoring methotrexate long-term ... Keywords: methotrexate, liver fibrosis, procollagen peptide ... to correlate well with evidence of hepatic fibrosis and managed using the Manchester protocol, UK. (1)Dermatology Centre, University of Manchester, Hope Hospital, Salford, ... BACKGROUND: Patients receiving long-term methotrexate for psoriasis are at risk ... Methotrexate for psoriasis in the era of biological therapy. ... Royal Hospital, University of Manchester, Manchester, UK. Mar 21, 2014 Physiologically based pharmacokinetic modelling of methotrexate and ... (1) Centre for Applied Pharmacokinetic Research, Manchester ... We read with interest the paper by Ranganathan et al proposing that pharmacogenetics may be a useful tool to help predict methotrexate (MTX) toxicity and ... 1Department of Paediatric Rheumatology, Royal Manchester Childrens Hospitals, ... Methotrexate (MTX) has transformed the outlook for children with juvenile ... Otrexup™ is a once-weekly medication that delivers subcutaneous methotrexate via an auto-injector.* *Otrexup [prescribing information], Ewing, NJ: Antares ... The non-surgical abortion procedure offers patients an alternative to surgical abortion early in their pregnancy. ... The non-surgical abortion is also referred to as a medical abortion or a medication abortion. ... Mifepristone/Misoprostol regimen - This method is often called the ... Minaur NJ(1), Kounali D, Vedi S, Compston JE, Beresford JN, Bhalla AK. ... OBJECTIVE: To determine the effect of methotrexate (MTX) on bone mineral density ... Weatherhead SC(1), Wahie S, Reynolds NJ, Meggitt SJ. ... Although methotrexate (MTX) is a widely used and effective treatment for psoriasis, there have been ... May 15, 2014 1Department of Internal Medicine, Mount Sinai School of Medicine, Jersey City Medical Center, 355 Grand Street, Jersey City, NJ 07302, USA arthritis examines methotrexate (MTX) responses using in vitro models and primary ...... [12] Maas K, Westfall M, Pietenpol J, Olsen NJ, Aune T. Reduced p53 in ... To test a novel strategy for overcoming intrinsic resistance to methotrexate (MTX) ... The Cancer Institute of NJ/Robert Wood Johnson Medical School, 195 Little ... Jan 15, 2014 EWING, N.J.--(BUSINESS WIRE)--Antares Pharma, Inc. (NASDAQ: ATRS) today an 1f84 nounced the availability of OTREXUP, the first U.S. Food ... Nearly Pain-free Self-administration of Subcutaneous Methotrexate With an .... The MTXAI (Otrexup™ [methotrexate], Antares Pharma, Ewing, NJ) was approved ... Steroids, non-steroidal anti-inflammatory medications, methotrexate, penicillamine and anticoagulants may all complicate the post-operative surgical course ...
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Possible Side Effects

Check with your doctor if any of these most common side effects persist or become bothersome:

dizziness; headache; loss of appetite; mild hair loss; nausea; stomach pain or upset; tiredness; vomiting.
Seek medical attention right away if any of these severe side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in the urine; calf or leg pain or swelling; change in the amount of urine; chest pain; coma; confusion; coughing up blood; dark urine; diarrhea; difficult or painful urination; dry cough; fever, chills, or sore throat; menstrual changes; mental or mood changes; mouth sores; one-sided weakness; red, swollen, peeling, or blistered skin; seizures; severe or persistent nausea or vomiting; shortness of breath; speech changes; unusual bleeding or bruising; unusual pain and discoloration of the skin; unusual tiredness or weakness; vision changes or vision loss; yellowing of skin or eyes.
More Information

Methotrexate is to be used only by the patient for whom it is prescribed. Do not share it with other people.

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