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Why is this medication prescribed?

Rectal mesalamine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), proctitis (swelling in the rectum), and proctosigmoiditis (swelling in the rectum and sigmoid colon [last section of the colon]). Rectal mesalamine is in a class of medications called anti-inflammatory agents. It works by stopping the body from producing a certain substance that may cause inflammation.

How should this medicine be used?

Rectal mesalamine comes as a suppository and an enema to use in the rectum. The suppository and the enema are usually used once a day at bedtime. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use rectal mesalamine exactly as directed. Do not use it more or less of it or use it more often than prescribed by your doctor.

You should begin to feel better during the first few days or weeks of your treatment with rectal mesalamine. Continue to use rectal mesalamine until you finish your prescription, even if you feel better at the beginning of your treatment. Do not stop using rectal mesalamine without talking to your doctor.

Mesalamine suppositories and enemas may stain clothing and other fabrics, flooring, and painted, marble, granite, enamel, vinyl, and other surfaces. Take precautions to prevent staining when you use these medications.

If using a mesalamine enema, follow these steps:

  1. Try to have a bowel movement. The medication will work best if your bowels are empty.
  2. Use scissors to cut the seal of the protective foil pouch that holds seven bottles of medication. Be careful not to squeeze or cut the bottles. Remove one bottle from the pouch.
  3. Look at the liquid inside the bottle. It should be off-white or tan colored. The liquid may darken slightly if the bottles are left out of the foil pouch for a time. You may use liquid that has darkened a little bit, but do not use liquid that is dark brown.
  4. Shake the bottle well to make sure the medication is mixed.
  5. Remove the protective cover from the applicator tip. Be careful to hold the bottle by the neck so that the medication will not leak out of the bottle.
  6. Lie on your left side with your lower (left) leg straight and your right leg bent toward your chest for balance. You can also kneel on a bed, resting your upper chest and one arm on the bed.
  7. Gently insert the applicator tip into your rectum, pointing it slightly toward your navel (belly button). If this causes pain or irritation, try putting a small amount of personal lubricating jelly or petroleum jelly on the tip of the applicator before you insert it.
  8. Hold the bottle firmly and tilt it slightly so that the nozzle is aimed toward your back. Squeeze the bottle slowly and steadily to release the medicine.
  9. Withdraw the applicator. Remain in the same position for at least 30 minutes to allow the medicine to spread through your intestine. Try to keep the medicine inside of your body for about 8 hours (while you sleep).
  10. Dispose of the bottle safely, so that is out of the reach of children and pets. Each bottle contains only one dose and should not be reused.

If using a mesalamine suppository, follow these steps:

  1. Try to have a bowel movement just before using the suppository. The medication will work best if your bowels are empty.
  2. Separate one suppository from the strip of suppositories. Hold the suppository upright and use your fingers to peel off the plastic wrapper. Try to handle the suppository as little as possible to avoid melting it with the heat of your hands.
  3. You may put a small amount of personal lubricant jelly or Vaseline on the tip of the suppository so that it will be easier to insert.
  4. Lie down on your left side and raise your right knee to your chest. (If you are left-handed, lie on your right side and raise your left knee.)
  5. Using your finger, insert the suppository into the rectum, pointed end first. Use gentle pressure to insert the suppository completely. Try to keep it in place for 1 to 3 hours or longer if possible.
  6. Wash your hands thoroughly before you resume your normal activities.

If you will be using mesalamine enemas or suppositories, ask your pharmacist or doctor for a copy of the manufacturer's information for the patient that comes with the medication.

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